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KNEE JOINT DISORDERS

Knee Joint Disorders

Adipose-derived stem cells support cartilage repair, anti-inflammatory action and functional recovery for chronic knee disease.

  • Cartilage Repair
  • Pain Relief
  • Mobility Recovery
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Beyond Painkillers and Replacement

Knee Joint Disease Deserves Regenerative, Not Just Palliative, Care

Knee pain, swelling, stiffness and grinding are early signs of cartilage breakdown that often progresses to osteoarthritis. Traditional treatment—medication, injections, surgery or replacement—addresses symptoms but rarely restores the cartilage surface. Stem-cell therapy, particularly local injection of adipose-derived MSCs into the joint, supports chondrocyte regeneration, anti-inflammatory modulation and gradual restoration of joint function.

Why Conventional Knee Therapy Often Fails Long-Term

A deeper, more considered approach

  • Painkillers reduce pain but cannot regenerate cartilage.
  • Hyaluronic acid injections provide only temporary lubrication.
  • Arthroscopic surgery cannot fully restore damaged cartilage.
  • Knee replacement involves long recovery and limited lifespan.
  • Patients face progressive loss of mobility and independence.

Cartilage & Joint Repair

Why Stem-Cell Therapy Is Changing Knee Joint Care

01

Chondrocyte Differentiation

Adipose-derived MSCs differentiate into chondrocyte-like cells, supporting cartilage surface repair.
02

Anti-Inflammatory Synovial Effect

Stem cells reduce synovial inflammation, lowering swelling and effusion.
03

Joint Microenvironment Improvement

Trophic factors restore synovial fluid quality and cartilage matrix metabolism.
04

Minimally Invasive Local Injection

Cells are delivered via intra-articular injection — no surgery, no general anesthesia.
05

Compatible with PRP Therapy

May be combined with PRP to create a favorable regenerative environment before stem-cell delivery.
06

Lower Long-Term Joint Risk

May delay or avoid the need for total knee replacement in selected patients.

Clinical Improvements

Improvements Patients May Experience

  • Marked reduction in walking and stair-climbing pain
  • Reduced swelling and joint effusion within weeks
  • Improved range of motion and joint flexibility
  • Visible cartilage thickening on follow-up MRI
  • Ability to discontinue canes, walkers or wheelchairs

Suitable Candidates

Designed for individual needs

  • Patients with mild to moderate knee osteoarthritis (K-L grade 2-3)
  • Patients with meniscus injury who want to preserve the joint
  • Post-knee-surgery patients with residual pain
  • Middle-aged and elderly patients hoping to delay joint replacement
  • Athletes with cartilage damage from sports overuse

Patient Stories

Observed changes and clinical stories

Stage-4 Knee Osteoarthritis — Elderly Patient

An 88-year-old woman with stage-4 knee osteoarthritis received a single autologous stem-cell injection. Walking ability and pain both improved markedly in follow-up.

Middle-Aged Patient Avoiding Replacement

A 71-year-old female with bilateral severe knee pain avoided total knee replacement after stem-cell therapy and returned to daily walking.

Private, professional, precise

Safety, Serenity, Reassurance — Your Triple Assurance

GINZA CLINIC is equipped with a Japanese medical-grade CPC laboratory. Consultation, collection, culture and reinfusion follow independent, standardized and stringent aseptic processes. One-to-one physician-led care protects privacy, peace of mind and efficiency.